Chronic inflammation in atopic dermatitis may be caused by dysfunctional sweating mechanisms

Because the primary cause of lesions in atopic dermatitis (AD) is some dysfunction in the permeability barrier and antimicrobial barrier of the skin, it makes sense to look at the sweat functions in individuals given that sweat brings bacteria and moisture through the skin. Researchers from the Kyorin University School of Medicine in Tokyo, Japan, have found that most AD patients have problems bringing sweat up through the skin when they get hot. They found that most patients compensated this problem by overproducing sweat, which in turn pours into the dermal tissues, causing chronic inflammation.

Source: Current Problems in Dermatology

May 2011

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